Not really difficult, you've basically an elevation and windage knob. Although it may not be the actual mechanical zero for the rifle, set your elevation and windage at the zeros on the scales of the sight. Shoot your first shots at 25 yards so you can see where you are hitting. Use a consistent sight picture/hold. I suspect your rifle has a post type front sight, so use a 6 o'clock hold and keep that sight picture consistent. Don't worry too much about trying to center the post in sight aperture. Your eye will usually do that naturally. If you have access to a laser bore sight you can do a pre-range zero too.